Together with School of Medicine and the Chao Family Comprehensive Cancer Center at the University of California, Irvine, the Masri laboratory operates the Center of Excellence for Metabolic Phenotyping (CEMP). The CEMP is operated in collaboration with TSE Systems and is housed in the Falling Leaves Foundation Medical Innovation Building.
The Masri lab operates the CEMP with the following equipment:
** PhenoMaster metabolic cages for indirect calorimetry analysis of mice. The CEMP operates 30 PhenoMaster metabolic cages that are equipped with ActiMot infrared beam technology spaced along the X/Y planes in the home cage to test for gross locomotor or fine-activity movement, quantitative measurement of food/water intake, oxygen and carbon dioxide ratios, voluntary wheel running activity, load-bearing wheel running activity, 13C sensors for real-time assessment of oxidation of metabolic substrates, body weight sensors, and other parameters to help define energy expenditure, respiratory exchange ratio, and overall health of the mice.
Additional instrumentation in the CEMP:
** EchoMRI for body composition
** DEXA scanner for tissue-specific isolation of body composition
** Grip Strength Meter
** Ultrasound with image-guided needle for orthotopic injections (this instrument bypasses the need for orthotopic injection survival surgeries that result in high animal mortality)
** SmartWaiter cages for automated time-restricted feeding and pair-wise feeding
** Entrainment room space for 500 cages for circadian studies that are strictly light, humidity, and temperature controlled.
Masri Laboratory 