Masri Laboratory

Research in the Masri lab is aimed at understanding how misalignment of the circadian clock, the internal biological pacemaker, is involved in cancer progression. Our lab is focused on dissecting the role of the circadian clock in multiple solid tumor types, including lung cancer, colorectal cancer, and pancreatic cancer. The Masri lab is focused on defining the interplay between the circadian clock and tumor immunity, response to immunotherapy, cancer metabolism, nutrition, genome integrity, and stemness. We utilize genetic mouse models of cancer, mouse and patient-derived organoid systems, and numerous computational platforms to dissect key questions in cancer biology.